Welcome to O2H
 
 
Welcome to O2H
 
O2h now a part of the Piramal group
 
O2h to provide chemistry support to Chromocell.
 

O2h to provide discovery support to Karyopharm Therapeutics

 
Heptares Therapeutics extends Multi-FTE collaboration with O2h
 
MRCT and O2h announce medicinal chemistry collaboraion. 
 
O2h attending Chem Outsourcing Conference
Long Branch NJ, USA, 12-15 September 2011 
 
O2h, part of Piramal CPhi stand
Contact us to arrange a dinner meeting on the 26th of October!
Frankfurt, Germany, 25-27 October 2011 
 
O2h attending BioEurope2011

Get in touch to meet with us! 

31 October - 2 November 2011
Dusseldorf, Germany
 
O2h attending Genesis
London, UK 1 December 2011
 
O2h attending JP Morgan
San Francisco, USA, 9-13 January 2012
 
 
 O2h Biology                  !!Click here for our ADME promotion!!
O2h has seen strong demand from its existing and potential clients to provide a full service drug discovery offering. O2h therefore are developing a combined internal and networked approach to creating centers of excellence in drug discovery to provide its clients with a complete discovery experience.
O2h Biology Affiliate Program
O2h believe that biology assays are very specialised and require expert capabilities developed over time. O2h has signed up two affiliate partners in the UK with biology expertise in CNS and oncology. O2h continues to broaden its affiliate network in centers of excellence to provide a broader discovery offering to its clients.
 
Seamless integration of on-site and affiliate partner expertise
O2h has introduced Biology Points Program to provide a seamless interface to our clients for both are on-site and external biology capabilities. O2h has allocated biology points to all available in-house assays below. The highlights of this system include,
 
Flexibility - Biology points can be used against any O2h/affiliate validated assay.
Cost Advantage - Cost per point decreases if more biology points are purchased togather.
Time Savings - purchase orders and negotiation for each assay are not required. 
Planning convinience - project leaders can be allocated biology points which they can use for their projects at their discretion.
O2h continually updates its list of in-house assays and thus the biology points allocated to each assay may change. The most up-to-date list can be viewed below:
 

 Assays

 Points/Compound

 Solution/Stability

Aq. Sol – Absolute

     2.5

Aq. Sol - Physiological pH

     2.5

Partition coefficient logD (n-octanol/PBS pH(7.4))

     3

Partition Coefficient logP (n-octanol/water)

     3

Chemical (pH) stability (per pH)

     3.5

  

 CYP Interactions  

CYP 450 Inhibition (per compound/per isoform)

     2

CYP450 - IC50 (per compound/per isoform)

     4

 

 Metabolic Stability

Metabolic stability in liver microsomes (Human/Rat/Mouse/Beagle Dog)

1.    % remaining per species

2.     t1/2 per species 

    

 

    8

    10

PAMPA

    4

BAMPA

    4
 
 
     
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