Welcome to O2H
 
 
Welcome to O2H
 
Heptares Therapeutics extends Multi-FTE collaboration with O2h
 
MRCT and O2h announce medicinal chemistry collaboraion. 
 
O2h at BIO2010 
Chicago, USA, 3-6May 2010 
 
O2h exhibiting at ERBI conference 2010 
Cambridge, UK, 2-3 June 2010 
 
CEO Sunil Shah speaking at SCI Drug Discovery Outsourcing Conference 2010 
London, UK, 9 June 2010 
 
O2h attending BIONJ 2010 
New Jersey, USA, 14-15 June 2010 
 
O2h attending  MassBio Signature event
Boston, USA, October 2010 
 
O2h attending ChemPharma Outsourcing 2010 
New Jersey, USA, 14-16 September 2010 
 
O2h attending BIO Europe 
Munich, Germany, 15-17 November 2010
 
 
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O2h has seen strong demand from its existing and potential clients to provide a full service drug discovery offering. O2h therefore are developing a combined internal and networked approach to creating centers of excellence in drug discovery to provide its clients with a complete discovery experience.
O2h Biology Affiliate Program
O2h believe that biology assays are very specialised and require expert capabilities developed over time. O2h has signed up two affiliate partners in the UK with biology expertise in CNS and oncology. O2h continues to broaden its affiliate network in centers of excellence to provide a broader discovery offering to its clients.
 
Seamless integration of on-site and affiliate partner expertise
O2h has introduced Biology Points Program to provide a seamless interface to our clients for both are on-site and external biology capabilities. O2h has allocated biology points to all available in-house assays below. The highlights of this system include,
 
Flexibility - Biology points can be used against any O2h/affiliate validated assay.
Cost Advantage - Cost per point decreases if more biology points are purchased togather.
Time Savings - purchase orders and negotiation for each assay are not required. 
Planning convinience - project leaders can be allocated biology points which they can use for their projects at their discretion.
O2h continually updates its list of in-house assays and thus the biology points allocated to each assay may change. The most up-to-date list can be viewed below:
 

 Assays

 Points/Compound

 Solution/Stability

Aq. Sol – Absolute

     2.5

Aq. Sol - Physiological pH

     2.5

Partition coefficient logD (n-octanol/PBS pH(7.4))

     3

Partition Coefficient logP (n-octanol/water)

     3

Chemical (pH) stability (per pH)

     3.5

  

 CYP Interactions  

CYP 450 Inhibition (per compound/per isoform)

     2

CYP450 - IC50 (per compound/per isoform)

     4

 

 Metabolic Stability

Metabolic stability in liver microsomes (Human/Rat/Mouse/Beagle Dog)

1.    % remaining per species

2.     t1/2 per species 

    

 

    4

     6 

PAMPA

     4

BAMPA

     4
 
 
Oxygen Healthcare Ltd   23, Cambridge Science park, CB4 0EY , UK   Tel : +44 (0) 1223 437014   info@o2h.com
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