Welcome to O2H
 
 
Welcome to O2H
 
Heptares Therapeutics extends Multi-FTE collaboration with O2h
 
MRCT and O2h announce medicinal chemistry collaboraion. 
 
O2h at BIO2010 
Chicago, USA, 3-6May 2010 
 
O2h exhibiting at ERBI conference 2010 
Cambridge, UK, 2-3 June 2010 
 
CEO Sunil Shah speaking at SCI Drug Discovery Outsourcing Conference 2010 
London, UK, 9 June 2010 
 
O2h attending BIONJ 2010 
New Jersey, USA, 14-15 June 2010 
 
O2h attending  MassBio Signature event
Boston, USA, October 2010 
 
O2h attending ChemPharma Outsourcing 2010 
New Jersey, USA, 14-16 September 2010 
 
O2h attending BIO Europe 
Munich, Germany, 15-17 November 2010
 
 
New User Register
Medicinal Chemistry
O2h has a wide range of expertise in medicinal chemistry to help accelerate the drug discovery process. O2h can provide medicinal chemistry input to hit-to-lead and lead optimisation projects as well as at the pre-clinical developmental stage. Specifically, the O2h team has demonstrated expertise in:
 
Lead Generation
 
•Ligand design for pre-defined targets
•Synthesis of a homologous or diverse series of compounds for drug discovery projects
•Design and generation of libraries of structurally related compounds (close structural analogs, bioisosters etc.)
•Combinatorial synthesis of general as well as focused libraries
•Quick search for surrogates of core chemical scaffold.
 
Lead Optimization and Structure Activity Relationship (SAR) studies
 
•Hit-to-lead and Lead optimization with consideration of prior art, patentability and other IP issues
•Computational chemistry and molecular modeling for the design of ligands
•Design of virtual library with chemical diversity
•Establishing structure-activity relationships
•Prioritizing compounds for in-vitro screening
•Generation of lead molecules using traditional/iterative medicinal chemistry approach
 
 
Oxygen Healthcare Ltd   23, Cambridge Science park, CB4 0EY , UK   Tel : +44 (0) 1223 437014   info@o2h.com
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